Non-viral vectors for gene therapy

About this book

As with studies involving viral transduction, the delivery of naked nucleic acids can be broken down into several transport steps, including (1) transport of nuclei acids from the site of injection to the liver, (2) exit of nucleic acids out of the liver vessel lumen into contact with hepatocytes, (3) uptake by hepatocytes, (4) entry into the cytoplasm, and (5) entry into the nucleus.