Environmental mutagenesis

About this book

Germ-line and somatic mutations are recognized as significant causes of human disease, and so the detection, identification and study of mutagens in the environment is of increasing importance. Environmental Mutagenesis describes our current knowledge of the molecular mechanisms of mutagenesis and assesses the role of mutagens in cancer and inherited disease. Full details are also provided on all the major in vivo and in vitro methods of mutagenicity testing, including recently developed methods such as fluorescence in situ hybridization (FISH), the use of genetically engineered cells, and transgene technology. This book presents a unique overview of the current status of mutagenicity research and genetic toxicology in the form of reviews by leading researchers in the field. It is essential reading for all with an interest in genetic toxicology and molecular carcinogenesis, including molecular geneticists, genetic counsellors and clinicians.