Gaunylate Cyclase (Developments in Molecular and Cellular Biochemistry)

About this book

The present day status of the mammalian membrane guanylate cyclase signal transduction field is based on four eureka findings: (1) The discovery of cyclic GMP and the existence of the membrane guanylate cyclase enzyme in the biological systems; (2) the demonstration that existence of this enzyme is independent of its soluble form; (3) the discovery of the first membrane guanylate cyclase, which showed that the membrane guanylate cyclase enzyme is a surface receptor; (4) the current realization that all membrane guanylate cyclases are not surface receptors, some of them are regulated by the intracellularly generated Ca2+ spikes in the sensory neurons.